Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

HIVdb Program: Mutation List Analysis


Protease, RT, and integrase mutations can be entered using either the text box or pull down menus (detailed usage is found below).

The output can then be customized to display mutation comments, mutation scores, and an optional identifier and date. For further explanations and sample datasets please see the Release Notes.

Reverse Transcriptase
 
Protease
 
Integrase
Enter Mutation List:

OR

Use The Pulldown Menus:
40 41 44 62
65 67 69 70
74 75 77 90
98 100 101 103
106 108 115 116
118 138 151 179
181 184 188 190
210 215 219 221
225 227 230 236
238 318 348
 
Enter Mutation List:

OR

Use The Pulldown Menus:
10 11 13 20
23 24 30 32
33 35 36 43
46 47 48 50
53 54 58 63
71 73 74 76
77 82 83 84
85 88 89 90
93
 
Enter Mutation List:

OR

Use The Pulldown Menus:
51 66 74 92
95 97 114 121
128 138 140 143
145 146 147 148
151 153 155 157
163 230 263
Output Analysis:
Mutation Scores
Mutation Comments
RESET
ANALYZE

Detailed usage

To use the text box, type each mutation in uppercase separated by one or more spaces (the consensus wildtype amino acids and separating commas are optional). If there is a mixture of more than one amino acid at a position, write both amino acids (an intervening slash is optional). Use lowercase "ins" to indicate an insertion and lowercase "del" to indicate a deletion; if you type a mixture of "i/n/s" or "ins", this will be assumed to be an insertation rather than a mixture, to avoid this, enter this mixture in uppercase (likewise for "del"). Otherwise, lowercase mutations are allowed.

The pulldown menus are implemented with Javascript. Each pulldown menu lists amino acids known to be associated with drug resistance as well as amino acids at drug-resistance positions that occur with a frequency of >=0.1% among treated or untreated patients. To enter an amino acid not in the list, click on the asterisk "*". If you have trouble using Javascript on your browser or if you wish to enter a mixture, you should use the textbox instead.